Human, insect and nematode caspases kill Saccharomyces cerevisiae independently of YCA1 and Aif1p

@article{Puryer2006HumanIA,
  title={Human, insect and nematode caspases kill Saccharomyces cerevisiae independently of YCA1 and Aif1p},
  author={Michelle A Puryer and Christine J Hawkins},
  journal={Apoptosis},
  year={2006},
  volume={11},
  pages={509-517}
}
This study characterised the impact of active metazoan apoptotic proteases (caspases) on Saccharomyces cerevisiae viability. Expression of active caspase-3 or caspase-8 in yeast ruptured plasma and nuclear membranes and dramatically impaired clonogenic survival, but did not damage DNA. Deletion of the proposed yeast apoptosis regulators YCA1 or Aif1p did not affect the ability of human, insect or nematode caspases to kill yeast. These data indicate that expression of active metazoan caspases… CONTINUE READING