HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing.

@article{Zhang2015HucMSCExosomeMS,
  title={HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing.},
  author={Bin Zhang and Mei Wang and Ai-hua Gong and Xu Zhang and Xiaodan Wu and Yanhua Zhu and Hui Shi and Lijun Wu and Wei Zhu and Hui Qian and Wenrong Xu},
  journal={Stem cells},
  year={2015},
  volume={33 7},
  pages={2158-68}
}
Mesenchymal stem cell-derived exosomes (MSC-Ex) play important roles in tissue injury repair, however, the roles of MSC-Ex in skin damage repair and its mechanisms are largely unknown. Herein, we examined the benefit of human umbilical cord MSC-derived exosome (hucMSC-Ex) in cutaneous wound healing using a rat skin burn model. We found that hucMSC-Ex-treated wounds exhibited significantly accelerated re-epithelialization, with increased expression of CK19, PCNA, collagen I (compared to collagen… CONTINUE READING
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