HucMSC‐Exosome Mediated‐Wnt4 Signaling Is Required for Cutaneous Wound Healing

@article{Zhang2015HucMSCExosomeMS,
  title={HucMSC‐Exosome Mediated‐Wnt4 Signaling Is Required for Cutaneous Wound Healing},
  author={B. Zhang and M. Wang and A. Gong and X. Zhang and X. Wu and Yan-hua Zhu and Hui Shi and L. Wu and W. Zhu and Hui Qian and Wenrong Xu},
  journal={STEM CELLS},
  year={2015},
  volume={33}
}
Mesenchymal stem cell‐derived exosomes (MSC‐Ex) play important roles in tissue injury repair, however, the roles of MSC‐Ex in skin damage repair and its mechanisms are largely unknown. Herein, we examined the benefit of human umbilical cord MSC‐derived exosome (hucMSC‐Ex) in cutaneous wound healing using a rat skin burn model. We found that hucMSC‐Ex‐treated wounds exhibited significantly accelerated re‐epithelialization, with increased expression of CK19, PCNA, collagen I (compared to collagen… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
Beta‐catenin regulates wound size and mediates the effect of TGF‐beta in cutaneous healing
  • S. Cheon, Q. Wei, +6 authors Benjamin A. Alman
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
  • 174
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.
  • 474
Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats
  • 240
Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.
  • 917
  • PDF
...
1
2
3
4
5
...