Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p.

@article{Wu2014HuaierSP,
  title={Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p.},
  author={Tangwei Wu and Weiqun Chen and Shuiyi Liu and Hongda Lu and Hui Wang and Deyong Kong and Xiaodong Huang and Qinzhi Kong and Yong Ning and Zhongxin Lu},
  journal={FEBS letters},
  year={2014},
  volume={588 12},
  pages={2107-14}
}
Various studies have reported that Huaier possesses anti-tumor effects. However, the mechanisms are not completely elucidated. Here, we found 66 differentially expressed miRNAs in Huaier-treated pulmonary adenocarcinoma A549 cells, with upregulation of miR-26b-5p. Transfection of A549 cells with miR-26b-5p mimic inhibited proliferation and induced apoptosis, while transfection of Huaier-treated A549 cells with a miR-26b-5p inhibitor reversed the effects of Huaier. EZH2 was verified as the… CONTINUE READING
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