HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay.

@article{Chang2010HuRUA,
  title={HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay.},
  author={Na Chang and Jie Yi and Gaier Guo and Xinwen Liu and Yongfeng Shang and Tanjun Tong and Qinghua Cui and Ming Zhan and Myriam Gorospe and Wengong Wang},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 15},
  pages={3875-86}
}
In this study, we show that HuR destabilizes p16(INK4) mRNA. Although the knockdown of HuR or AUF1 increased p16 expression, concomitant AUF1 and HuR knockdown had a much weaker effect. The knockdown of Ago2, a component of the RNA-induced silencing complex (RISC), stabilized p16 mRNA. The knockdown of HuR diminished the association of the p16 3' untranslated region (3'UTR) with AUF1 and vice versa. While the knockdown of HuR or AUF1 reduced the association of Ago2 with the p16 3'UTR, Ago2… CONTINUE READING
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