HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

Abstract

Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has profound anticancer activity. Pharmacologic inhibitors can overcome the limitations of genetic inhibition. In this study, we examined the antitumor activity of CMLD-2, a small… (More)
DOI: 10.1038/s41598-017-07787-4

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