HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop.

@article{Singh2013HuRIA,
  title={HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop.},
  author={Mamata Singh and Alaina R Martinez and Suman Govindaraju and Beth S. M. Lee},
  journal={Journal of cellular physiology},
  year={2013},
  volume={228 1},
  pages={182-9}
}
Human antigen R (HuR) is a post-transcriptional regulator of gene expression that plays a key role in stabilizing mRNAs during cellular stress, leading to enhanced survival. HuR expression is tightly regulated through multiple transcription and post-transcriptional controls. Although HuR is known to stabilize a subset of mRNAs involved in cell survival, its role in the survival pathway of PI3-kinase/Akt signaling is unclear. Here, we show that in renal proximal tubule cells, HuR performs a… CONTINUE READING

Similar Papers

Loading similar papers…