Hu antigen R (HuR) multimerization contributes to glioma disease progression.

  title={Hu antigen R (HuR) multimerization contributes to glioma disease progression.},
  author={Natalia E Filippova and Xiuhua Yang and Subramaniam Ananthan and Anastasia Sorochinsky and James R. Hackney and Zachery Gentry and Sejong Bae and Peter H King and Louis B Nabors},
  journal={The Journal of biological chemistry},
  volume={292 41},
Among primary brain cancers, gliomas are the most deadly and most refractory to current treatment modalities. Previous reports overwhelmingly support the role of the RNA-binding protein Hu antigen R (HuR) as a positive regulator of glioma disease progression. HuR expression is consistently elevated in tumor tissues, and a cytoplasmic localization appears essential for HuR-dependent oncogenic transformation. Here, we report HuR aggregation (multimerization) in glioma and the analysis of this… CONTINUE READING
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