HtrA2 deficiency causes mitochondrial uncoupling through the F1F0-ATP synthase and consequent ATP depletion

@inproceedings{PlunFavreau2012HtrA2DC,
  title={HtrA2 deficiency causes mitochondrial uncoupling through the F1F0-ATP synthase and consequent ATP depletion},
  author={Helene Plun-Favreau and Victoria S. Burchell and Kira M. Holmstr{\"o}m and Zhi Lei Yao and Emma Deas and Kelvin Cain and Valentina Fedele and Nicoleta Moisoi and Michelangelo Campanella and L Miguel Martins and Nicholas Wood and Alexander V. Gourine and Andrey Y Abramov},
  booktitle={Cell Death and Disease},
  year={2012}
}
Loss of the mitochondrial protease HtrA2 (Omi) in mice leads to mitochondrial dysfunction, neurodegeneration and premature death, but the mechanism underlying this pathology remains unclear. Using primary cultures from wild-type and HtrA2-knockout mice, we find that HtrA2 deficiency significantly reduces mitochondrial membrane potential in a range of cell types. This depolarisation was found to result from mitochondrial uncoupling, as mitochondrial respiration was increased in HtrA2-deficient… CONTINUE READING

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Bioenergetics 3. 3rd edn

  • DG Nicholls, SJ Ferguson, DGB. Nicholls
  • 2002
Highly Influential
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