HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.

@article{Sekine2005HtrA2CA,
  title={HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.},
  author={Keiko Sekine and Yanyan Hao and Yasuyuki Suzuki and Ryosuke Takahashi and Takashi Tsuruo and Mikihiko Naito},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={330 1},
  pages={
          279-85
        }
}
Apollon/BRUCE is a giant IAP protein that has BIR and UBC domains in its amino- and carboxy-terminals, respectively. Apollon binds and ubiquitylates SMAC/DIABLO and caspase9, and regulates apoptosis by facilitating proteasomal degradation of these proteins. Apollon overexpression inhibits apoptosis, while its downregulation sensitizes cells to apoptosis, suggesting that Apollon level is important for apoptosis regulation. Here we show that HtrA2/Omi catalytically cleaves Apollon with its serine… CONTINUE READING
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IAPs: Modular regulators of cell signalling.

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