Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production.

@article{Chen2011Hsp90RN,
  title={Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production.},
  author={Feng Chen and Deepesh R Pandey and Ahmed Chadli and John D. Catravas and Teng Chen and David Fulton},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={14 11},
  pages={
          2107-19
        }
}
The goal of this study was to identify whether heat-shock protein 90 (Hsp90) regulates the production of superoxide and other reactive oxygen species from the NADPH oxidases (Nox). We found that pharmacological and genetic inhibition of Hsp90 directly reduced Nox5-derived superoxide without secondarily modifying signaling events. Coimmunoprecipitation and bioluminescence resonance energy transfer studies suggest that the C-terminus of Nox5 binds to Hsp90. Long-term Hsp90 inhibition reduced Nox5… CONTINUE READING
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Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones.

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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation.

The Journal of biological chemistry • 2007
View 8 Excerpts
Highly Influenced

NOX enzymes and the biology of reactive oxygen

Nature Reviews Immunology • 2004
View 6 Excerpts
Highly Influenced

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET).

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 8 Excerpts
Highly Influenced