Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.

@article{Cowen2005Hsp90PT,
  title={Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.},
  author={Leah E Cowen and Susan Lindquist},
  journal={Science},
  year={2005},
  volume={309 5744},
  pages={2185-9}
}
Hsp90 is a molecular chaperone for many signal transducers and may influence evolution by releasing previously silent genetic variation in response to environmental change. In fungi separated by approximately 800 million years of evolution, Hsp90 potentiated the evolution of drug resistance in a different way, by enabling new mutations to have immediate phenotypic consequences. Resistance was abrogated by Hsp90 inhibitors and by febrile temperatures, suggesting new therapeutic strategies and a… CONTINUE READING
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