Hsp90 molecular chaperone inhibitors: are we there yet?

@article{Neckers2012Hsp90MC,
  title={Hsp90 molecular chaperone inhibitors: are we there yet?},
  author={Leonard M. Neckers and Paul Workman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 1},
  pages={
          64-76
        }
}
Heat shock protein (Hsp) 90 is an ATP-dependent molecular chaperone that is exploited by malignant cells to support activated oncoproteins, including many cancer-associated kinases and transcription factors, and it is essential for oncogenic transformation. Originally viewed with skepticism, Hsp90 inhibitors are now being actively pursued by the pharmaceutical industry, with 17 agents having entered clinical trials. Investigators established Hsp90's druggability using the natural products… CONTINUE READING

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