Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome.

@article{Quadroni2015Hsp90II,
  title={Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome.},
  author={Manfredo Quadroni and Alexandra Potts and Patrice Waridel},
  journal={Journal of proteomics},
  year={2015},
  volume={120},
  pages={215-29}
}
UNLABELLED Inhibition of the essential chaperone Hsp90 with drugs causes a global perturbation of protein folding and the depletion of direct substrates of Hsp90, also called clients. Ubiquitination and proteasomal degradation play a key role in cellular stress responses, but the impact of Hsp90 inhibition on the ubiquitinome has not been characterized on a… CONTINUE READING