Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment.

@article{Chen2014Hsp90CI,
  title={Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment.},
  author={Yaomin Chen and Bin Wang and Dan Liu and Jing Jing Li and Yueqiang Xue and Kazuko Sakata and Ling-Qiang Zhu and Scott A. Heldt and Huaxi Xu and Francesca Fang Liao},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 7},
  pages={
          2464-70
        }
}
The excessive accumulation of soluble amyloid peptides (Aβ) plays a crucial role in the pathogenesis of Alzheimer's disease (AD), particularly in synaptic dysfunction. The role of the two major chaperone proteins, Hsp70 and Hsp90, in clearing misfolded protein aggregates has been established. Despite their abundant presence in synapses, the role of these chaperones in synapses remains elusive. Here, we report that Hsp90 inhibition by 17-AAG elicited not only a heat shock-like response but also… CONTINUE READING
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