Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response.

Abstract

Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an essential role in cell growth and survival. The chaperone exerts these functions by regulating key signaling proteins involved in cell growth/survival and protecting cells from proteotoxic stress. Importantly, Hsp90 inhibitors including geldanamycin analogues show anti-tumor effects. We… (More)

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Cite this paper

@article{Yamashita2007Hsp90AT, title={Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response.}, author={Takayuki Yamashita and Tsukasa Oda and Takayuki Sekimoto}, journal={Cell cycle}, year={2007}, volume={6 18}, pages={2232-5} }