Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals.

Abstract

Botulinum (BoNTs) and tetanus (TeNT) neurotoxins are the most toxic substances known and form the growing family of Clostridial neurotoxins (CNT), the etiologic agents of botulism and tetanus. CNT are composed of a metalloprotease light chain (L), linked via a disulfide bond to a heavy chain (H). H mediates the binding to nerve terminals and the membrane… (More)
DOI: 10.1016/j.toxicon.2017.10.028

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@article{Pirazzini2017Hsp90AT, title={Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals.}, author={Marco Pirazzini and Domenico Azarnia Tehran and Giulia Zanetti and Ornella Rossetto and Cesare Montecucco}, journal={Toxicon : official journal of the International Society on Toxinology}, year={2017} }