Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

  title={Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.},
  author={Hua Zhang and Wei Wu and Yan Du and Sarah J Santos and Susan E. Conrad and Jack Throck Watson and Nicholas Grammatikakis and Kathleen A. Gallo},
  journal={The Journal of biological chemistry},
  volume={279 19},
Mixed-lineage kinase 3 (MLK3) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates MAPK pathways, including the c-Jun NH(2)-terminal kinase (JNK) and p38 pathways. MLK3 and its family members have been implicated in JNK-mediated apoptosis. A survey of human cell lines revealed high levels of MLK3 in breast cancer cells. To learn more about MLK3 regulation and its signaling pathways in breast cancer cells, we engineered the estrogen-responsive human breast cancer cell line… CONTINUE READING


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Hsp90/p50 Regulates MLK3 Signaling

F. B. Dunn
J. Natl. Cancer Inst. 94, • 2002

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