Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

@article{Grover2011Hsp90Cdc37CC,
  title={Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A},
  author={A. Grover and Ashutosh Shandilya and V. Agrawal and P. Pratik and Divya Bhasme and V. Bisaria and D. Sundar},
  journal={BMC Bioinformatics},
  year={2011},
  volume={12},
  pages={S30 - S30}
}
BackgroundHSPs (Heat shock proteins) are highly conserved ubiquitous proteins among species which are involved in maintaining appropriate folding and conformation of other proteins and are thus referred to as molecular chaperones. Hsp90 (Heat-shock protein 90 kDa) is one of a group of molecular chaperones responsible for managing protein folding and quality control in cell environment. However it is also involved in the maturation and stabilization of a wide range of oncogenic client proteins… Expand
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