Hsp70 response to 5-fluorouracil treatment in human colon cancer cell lines

@article{Grivicich2007Hsp70RT,
  title={Hsp70 response to 5-fluorouracil treatment in human colon cancer cell lines},
  author={Ivana Grivicich and Andr{\'e}a Regner and Caroline Zanoni and Larissa Proc{\'o}pio Correa and Geraldo Pereira Jotz and Jo{\~a}o Antonio P{\^e}gas Henriques and Gilberto Schwartsmann and Adriana Brondani da Rocha},
  journal={International Journal of Colorectal Disease},
  year={2007},
  volume={22},
  pages={1201-1208}
}
Colorectal cancer is a common disease with high rate of mortality. Although there is evidence of some benefits of 5-fluorouracil (5-FU), the most commonly used drug in colon cancer therapy, it still remains unsatisfactory because of intrinsic or acquired drug resistance. Heat shock proteins (Hsps) synthesis can be increased by cellular insults, such as chemotherapy-induced damage. Inducible Hsp70 has been suggested to be involved in cytoprotection against apoptosis. In the present study, we… CONTINUE READING