Hsp70 release from peripheral blood mononuclear cells.

  title={Hsp70 release from peripheral blood mononuclear cells.},
  author={Claire Hunter-Lavin and Emma L. Davies and Maria M F V G Bacelar and Michael John Marshall and Sarah M. Andrew and John H H Williams},
  journal={Biochemical and biophysical research communications},
  volume={324 2},
There are an increasing number of studies reporting the presence of Hsps in human serum. We have investigated the release of Hsp70 into blood and culture medium from peripheral blood mononuclear cells (PBMCs), and whether this release is due to cell damage or active secretion from the cells. Intact Hsp70 was released from cells within whole blood and from purified PBMCs under normal culture conditions. Hsp70 release was rapid (0.1 ng/10(6) cells/h) over the first 2 h of culture and continued at… CONTINUE READING


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