Hsp70 may protect cardiomyocytes from stress-induced injury by inhibiting Fas-mediated apoptosis.

@article{Zhao2007Hsp70MP,
  title={Hsp70 may protect cardiomyocytes from stress-induced injury by inhibiting Fas-mediated apoptosis.},
  author={Yun M. Zhao and Wanyin Wang and Lingjia Qian},
  journal={Cell stress & chaperones},
  year={2007},
  volume={12 1},
  pages={83-95}
}
Expression of Hsp70 is an endogenous mechanism by which living cells adapt to stress and the protection of Hsp70 may interfere with the apoptotic machinery in a variety of ways. Here, we observed the change of Hsp70 expression in rat myocardium under stress and explored the protective effect of Hsp70 on the Fas-mediated pathway to cardiomyocyte apoptosis. The results showed that restraint stress led to cardiac dysfunction and structural damage of the myocardium, as well as activation of the Fas… CONTINUE READING

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