Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.

  title={Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.},
  author={Adam R. Stankiewicz and Guillaume Lachapelle and Cheryl P Z Foo and Stefanie M. Radicioni and Dick D. Mosser},
  journal={The Journal of biological chemistry},
  volume={280 46},
Hsp70 overexpression can protect cells from stress-induced apoptosis. Our previous observation that Hsp70 inhibits cytochrome c release in heat-stressed cells led us to examine events occurring upstream of mitochondrial disruption. In this study we examined the effects of heat shock on the proapoptotic Bcl-2 family member Bax because of its central role in regulating cytochrome c release in stressed cells. We found that heat shock caused a conformational change in Bax that leads to its… CONTINUE READING
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