Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death

  title={Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death},
  author={Mona Taleb and Carlene S. Brandon and Fu-shing Lee and Kelly C. Harris and Wolfgang H. Dillmann and Lisa L Cunningham},
  journal={Cell Stress and Chaperones},
Sensory hair cells of the inner ear are sensitive to death from aging, noise trauma, and ototoxic drugs. Ototoxic drugs include the aminoglycoside antibiotics and the antineoplastic agent cisplatin. Exposure to aminoglycosides results in hair cell death that is mediated by specific apoptotic proteins, including c-Jun N-terminal kinase (JNK) and caspases. Induction of heat shock proteins (Hsps) can inhibit JNK- and caspase-dependent apoptosis in a variety of systems. We have previously shown… CONTINUE READING
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