Hsp70 alters tau function and aggregation in an isoform specific manner.

@article{Voss2012Hsp70AT,
  title={Hsp70 alters tau function and aggregation in an isoform specific manner.},
  author={Kellen Ranero Voss and Benjamin Combs and Kristina R Patterson and Lester I. Binder and Truman C Gamblin},
  journal={Biochemistry},
  year={2012},
  volume={51 4},
  pages={888-98}
}
Tauopathies are characterized by abnormal aggregation of the microtubule associated protein tau. This aggregation is thought to occur when tau undergoes shifts from its native conformation to one that exposes hydrophobic areas on separate monomers, allowing contact and subsequent association into oligomers and filaments. Molecular chaperones normally… CONTINUE READING