Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin

@article{Bhadra2015Hsp47MC,
  title={Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin},
  author={Joyita Bhadra and M Kathryn Iovine},
  journal={Mechanisms of Development},
  year={2015},
  volume={138},
  pages={364-374}
}
Skeletal morphogenesis describes how bones achieve their correct shape and size and appropriately position joints. We use the regenerating caudal fin of zebrafish to study this process. Our examination of the fin length mutant short fin (sof (b123)) has revealed that the gap junction protein Cx43 is involved in skeletal morphogenesis by promoting cell proliferation and inhibiting joint formation, thereby coordinating skeletal growth and patterning. Here we demonstrate that serpinh1b is… CONTINUE READING
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