Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae

@inproceedings{Specht2011Hsp42IR,
  title={Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae},
  author={Sebastian Specht and Stephanie B. M. Miller and Axel Mogk and Bernd Bukau},
  booktitle={The Journal of cell biology},
  year={2011}
}
The aggregation of proteins inside cells is an organized process with cytoprotective function. In Saccharomyces cerevisiae, aggregating proteins are spatially sequestered to either juxtanuclear or peripheral sites, which target distinct quality control pathways for refolding and degradation. The cellular machinery driving the sequestration of misfolded proteins to these sites is unknown. In this paper, we show that one of the two small heat shock proteins of yeast, Hsp42, is essential for the… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Activation of the chaperone Hsp 26 is controlled by the rearrangement of its ther - mosensor domain

  • R. García-Mata, Z. Bebök, E. J. Sorscher, E. S. Sztul
  • Mol . Cell .
  • 2008

Similar Papers

Loading similar papers…