Hsp40 function in yeast prion propagation: Amyloid diversity necessitates chaperone functional complexity

Abstract

Yeast prions are heritable protein-based elements, most of which are formed of amyloid aggregates that rely on the action of molecular chaperones for transmission to progeny. Prions can form distinct amyloid structures, known as 'strains' in mammalian systems, that dictate both pathological progression and cross-species infection barriers. In yeast these… (More)
DOI: 10.1080/19336896.2015.1020268

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