Hsp27 negatively regulates cell death by interacting with cytochrome c

  title={Hsp27 negatively regulates cell death by interacting with cytochrome c},
  author={Jean-Marie Bruey and C{\'e}cile Ducasse and Philippe Bonniaud and Luigi Ravagnan and Santos A Susin and Chantal Diaz-latoud and Sandeep Gurbuxani and Andr{\'e}-Patrick Arrigo and Guido Kroemer and {\'E}ric Solary and Carmen Garrido},
  journal={Nature Cell Biology},
Mammalian cells respond to stress by accumulating or activating a set of highly conserved proteins known as heat-shock proteins (HSPs). Several of these proteins interfere negatively with apoptosis. We show that the small HSP known as Hsp27 inhibits cytochrome-c-mediated activation of caspases in the cytosol. Hsp27 does not interfere with granzyme-B-induced activation of caspases, nor with apoptosis-inducing factor-mediated, caspase-independent, nuclear changes. Hsp27 binds to cytochrome c… CONTINUE READING
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