Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.

@article{Ciocca2003Hsp25AH,
  title={Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.},
  author={Daniel Ram{\'o}n Ciocca and Viviana Rosa Rozados and Fernando Dar{\'i}o Cuello Carri{\'o}n and Silvia I. Gervasoni and Pablo Matar and Olga Graciela Scharovsky},
  journal={Cell stress & chaperones},
  year={2003},
  volume={8 1},
  pages={26-36}
}
Heat shock protein 27 (Hsp27) and Hsp70 have been involved in resistance to anticancer drugs in human breast cancer cells growing in vitro and in vivo. In this study, we examined the expression of Hsp25 (the rodent homologue to human Hsp27) and Hsp70 in 3 different rodent tumors (a mouse breast carcinoma, a rat sarcoma, and a rat lymphoma maintained by subcutaneous passages) treated in vivo with doxorubicin (DOX) and lovastatin (LOV). All tumors showed massive cell death under control untreated… CONTINUE READING