Hsp-70 is closely associated with the transferrin receptor in exosomes from maturing reticulocytes.

@article{Mathew1995Hsp70IC,
  title={Hsp-70 is closely associated with the transferrin receptor in exosomes from maturing reticulocytes.},
  author={Alex Mathew and Alisa Bell and Rose M. Johnstone},
  journal={The Biochemical journal},
  year={1995},
  volume={308 ( Pt 3)},
  pages={
          823-30
        }
}
The presence of the heat shock protein (hsp-70) has been detected in exocytosed vesicles (which are named exosomes) from mammalian and avian immature red cells (i.e. reticulocytes) as well as from a differentiating avian erythroleukaemic cell line. The close, but non-covalent, association of hsp-70 with the transferrin receptor (TFR) in exosomes is demonstrated by: (1) the ability to cross-link hsp-70 to TFR; (2) the co-immunoprecipitation of hsp-70 and TFR with an antibody against TFR, and the… CONTINUE READING
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