Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation.

@article{Shyu2008HsiantsaoP,
  title={Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation.},
  author={Ming-Huan Shyu and Tzu-Chien Kao and G L Yen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2008},
  volume={46 12},
  pages={3707-13}
}
In this study, the protective effect of extract of Hsian-tsao (Mesona procumbens) (EHT) against liver fibrogenesis in carbon tetrachloride (CCl(4))-injured rats was evaluated. The inhibitory effect of oleanolic acid (OA) and ursolic acid (UA), which are the active compounds in EHT, on the activation of hepatic stellate cells (HSC) was also determined. The results showed that EHT at a dosage of 1.2g/kg of b.w. significantly reduced the liver injury induced by CCl(4) in rats. It also decreased… CONTINUE READING
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