Hsd11b2 haploinsufficiency in mice causes salt sensitivity of blood pressure.

Abstract

Salt sensitivity of blood pressure is an independent risk factor for cardiovascular morbidity. Mechanistically, abnormal mineralocorticoid action and subclinical renal impairment may blunt the natriuretic response to high sodium intake, causing blood pressure to rise. 11β-Hydroxysteroid dehydrogenase type 2 (11βHSD2) controls ligand access to the… (More)
DOI: 10.1161/HYPERTENSIONAHA.110.163782

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