Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli.

@article{Yoshimune2002Hsc62HA,
  title={Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli.},
  author={Kazuaki Yoshimune and Ryokei Yoshimura and T{\^o}ru Nakayama and Tokuzo Nishino and Nobuyoshi Esaki},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={293 5},
  pages={
          1389-95
        }
}
Hsc62 is the third Hsp70 homolog of Escherichia coli, which we found previously. Hsc62 is structurally and biochemically similar to DnaK, but hscC gene encoding Hsc62 did not compensate for the defects in the dnaK-null mutant of E. coli MC4100 strain. We cloned the ybeV gene and purified the gene product named Hsc56, a 55,687-Da protein with a J-domain like sequence. Hsc56 stimulated the ATPase activity of only Hsc62 but not those of the other Hsp70 homologs, DnaK and Hsc66. Hsc56 contains the… CONTINUE READING
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