Hsa-mir-127 impairs survival of patients with glioma and promotes proliferation, migration and invasion of cancerous cells by modulating replication initiator 1

@article{Wang2018Hsamir127IS,
  title={Hsa-mir-127 impairs survival of patients with glioma and promotes proliferation, migration and invasion of cancerous cells by modulating replication initiator 1},
  author={Yunling Wang and Yihai Lin},
  journal={NeuroReport},
  year={2018},
  volume={29},
  pages={1166–1173}
}
This work aimed to investigate the inter-regulatory functions of hsa-mir-127 and replication initiator 1 (REPIN1) on the proliferation and metastasis of glioma cells. The in-silico data on the implication of hsa-mir-127 and REPIN1 in glioma were retrieved from The Cancer Genome Atlas (TCGA). The expression levels of hsa-mir-127 and REPIN1 mRNA were determined by qRT-PCR, whereas Western blot was used to detect REPIN1 protein expression in glioma cell lines. The proliferation of glioma cells was… 
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References

SHOWING 1-10 OF 42 REFERENCES
MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7.
TLDR
It is shown that miR-127-3p promoted cell migration and invasion of GBM cells using in vitro cell lines and in vivo mouse models and identified SEPT7, a known tumor-suppressor gene that has been reported to suppress GBM cell Migration and invasion, as a direct target of miR+3p.
MicroRNA-1273 p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT 7
TLDR
It is shown that miR-127-3p promoted cell migration and invasion of GBM cells using in vitro cell lines and in vivo mouse models and identified SEPT7, a known tumor-suppressor gene that has been reported to suppress GBM cell Migration and invasion, as a direct target of miR+3p.
MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells.
MicroRNA-127 Post-Transcriptionally Downregulates Sept7 and Suppresses Cell Growth in Hepatocellular Carcinoma Cells
Background/Aims: Hepatocellular carcinoma is one of the most common cancers worldwide. It has been suggested that microRNAs, a class of small regulatory RNAs, are associated with tumorigenesis by
MicroRNA-127 is aberrantly downregulated and acted as a functional tumor suppressor in human pancreatic cancer
TLDR
In lentivirus-infected capan-1 and PANC-1 cells, miR-127 overexpression significantly inhibited cancer progression, cell-cycle transition and invasion in vitro, as well as tumorigenicity in vivo, and human BAG5 was confirmed to be the downstream target of microRNA-127 in pancreatic cancer.
Knockdown of microRNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells.
  • R. FengLei Dong
  • Biology, Chemistry
    International journal of clinical and experimental pathology
  • 2015
TLDR
The data indicate that down-regulation of micorRNA-127 can trigger apoptosis and overcome drug resistance of gliomas cells, and this resistance of adriamycin in glioma can be cancelled by silencing expression of micro RNA-127.
Prognostic and Biological Significance of MicroRNA-127 Expression in Human Breast Cancer
TLDR
Functional analyses showed that upregulation of miR-127 significantly inhibited growth, enhanced apoptosis, and reduced migration and invasion in BC cells by targeting the protooncogene BCL-6, which may be a molecular target for treatment of human BCs.
p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer.
TLDR
A double-negative feedback loop involving miR-15a/16-1 and AP4 that stabilizes epithelial and mesenchymal states, respectively, which may determine metastatic prowess is reported.
High expression of microRNA‑127 is involved in cell cycle arrest in MC‑3 mucoepidermoid carcinoma cells.
microRNAs (miRs) are small endogenous non‑coding RNAs and are associated with the pathogenesis of a number of types of human cancer. However, miR‑127‑3p in mucoepidermoid carcinoma (MEC) has not been
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