Hsa-mir-1269 genetic variant contributes to hepatocellular carcinoma susceptibility through affecting SOX6.

@article{Xiong2015Hsamir1269GV,
  title={Hsa-mir-1269 genetic variant contributes to hepatocellular carcinoma susceptibility through affecting SOX6.},
  author={Guanying Xiong and Yun Hui Wang and Quchen Ding and Lihua Yang},
  journal={American journal of translational research},
  year={2015},
  volume={7 10},
  pages={2091-8}
}
MiR-1269 is an essential oncogene that plays crucial roles in regulating the development of hepatocellular carcinoma (HCC). In this study, we mainly focused on the polymorphisms (rs73239138) in miR-1069 to explore its potential role in regulation of target genes in liver cancer. We detected increased level of miR-1269 in 80 HCC patients. SOX6 was predicted as a potential target gene of miR-as. Notably, Pearson correlation analysis indicated that patients harbored with miR-1269 wild type… CONTINUE READING

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