HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.

Abstract

In yeast, Atg4/Apg4 is a unique cysteine protease responsible for the cleavage of the carboxyl terminus of Atg8/Apg8/Aut7, a reaction essential for its lipidation during the formation of autophagosomes. However, it is still unclear whether four human Atg4 homologues cleave the carboxyl termini of the three human Atg8 homologues, microtubule-associated… (More)

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@article{Tanida2004HsAtg4BHsApg4Bautophagin1CT, title={HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.}, author={Isei Tanida and Yu-shin Sou and Junji Ezaki and Naoko Minematsu-Ikeguchi and Takashi Ueno and Eiki Kominami}, journal={The Journal of biological chemistry}, year={2004}, volume={279 35}, pages={36268-76} }