Hrs and endocytic sorting of ubiquitinated membrane proteins.

  title={Hrs and endocytic sorting of ubiquitinated membrane proteins.},
  author={Camilla Raiborg and Harald Stenmark},
  journal={Cell structure and function},
  volume={27 6},
Endocytosed receptors are either recycled to the plasma membrane or trapped within intralumenal vesicles of multi-vesicular bodies for subsequent degradation in lysosomes. How the cell is able to sort receptors in endosomes has so far been largely unknown. The hepatocyte growth factor regulated tyrosine kinase substrate, Hrs, is an essential protein that has been implicated in cell signalling and intracellular membrane trafficking. Very recently, several reports have demonstrated a role for Hrs… CONTINUE READING