Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.

@article{Bochman2014Hrq1AH,
  title={Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.},
  author={Matthew L Bochman and Katrin Paeschke and Angela P. S. Chan and Virginia A. Zakian},
  journal={Cell reports},
  year={2014},
  volume={6 2},
  pages={
          346-56
        }
}
Human RecQ4 (hRecQ4) affects cancer and aging but is difficult to study because it is a fusion between a helicase and an essential replication factor. Budding yeast Hrq1 is homologous to the disease-linked helicase domain of RecQ4 and, like hRecQ4, is a robust 3'-5' helicase. Additionally, Hrq1 has the unusual property of forming heptameric rings. Cells lacking Hrq1 exhibited two DNA damage phenotypes: hypersensitivity to DNA interstrand crosslinks (ICLs) and telomere addition to DNA breaks… CONTINUE READING
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Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase

  • Nucleic acids research
  • 2017
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