Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria.

@article{ChicoCalero2002HptAB,
  title={Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria.},
  author={Isabel Chico-Calero and M{\'o}nica Su{\'a}rez and Bruno Gonz{\'a}lez-Zorn and Mariela Scortti and J{\"o}rg Slaghuis and W. Goebel and Jose Vazquez-Boland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 1},
  pages={431-6}
}
Efficient replication in vivo is essential for a microparasite to colonize its host and the understanding of the molecular mechanisms by which microbial pathogens grow within host tissues can lead to the discovery of novel therapies to treat infection. Here we present evidence that the foodborne bacterial pathogen Listeria monocytogenes, a facultative intracellular parasite, exploits hexose phosphates (HP) from the host cell as a source of carbon and energy to fuel fast intracellular growth. HP… CONTINUE READING
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Gram-Positive Pathogens

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