Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells

@article{Wu2002Hp95PA,
  title={Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells},
  author={Ying Ping Wu and Shujuan Pan and Weiping Luo and Sue-Hwa Lin and Jian Kuang},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={6801-6808}
}
Abstractp95 is a putative signal transduction protein of ∼95 kDa that contains multiple tyrosine residues that are conserved from yeast to human, a Src phosphorylation consensus sequence and a proline-rich C-terminus that binds SH3-domains. Previous studies have established that mammalian p95 is physically associated with proteins that regulate apoptotic induction and cell transformation; however, it is unclear whether p95 is a positive or negative regulator in these processes. Moreover, a p95… CONTINUE READING

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