Hoxb5 marks long-term haematopoietic stem cells revealing a homogenous perivascular niche

@inproceedings{Chen2016Hoxb5ML,
  title={Hoxb5 marks long-term haematopoietic stem cells revealing a homogenous perivascular niche},
  author={James Yok-Jen Chen and Masanori Miyanishi and Sean K. Wang and Satoshi Yamazaki and Rahul Sinha and Kevin S. Kao and Hiromitsu Nakauchi and Irving L Weissman},
  booktitle={Nature},
  year={2016}
}
Haematopoietic stem cells (HSCs) are arguably the most extensively characterized tissue stem cells. Since the identification of HSCs by prospective isolation, complex multi-parameter flow cytometric isolation of phenotypic subsets has facilitated studies on many aspects of HSC biology, including self-renewal, differentiation, ageing, niche, and diversity. Here we demonstrate by unbiased multi-step screening, identification of a single gene, homeobox B5 (Hoxb5, also known as Hox-2.1), with… CONTINUE READING
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