Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.

@article{Ohno2010Hoxb4TD,
  title={Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.},
  author={Yoshinori Ohno and Shin'ichiro Yasunaga and Motoaki Ohtsubo and Sayaka Mori and Miyuki Tsumura and Satoshi Okada and Tomohiko Ohta and Kiyoshi Ohtani and Masao Kobayashi and Yoshihiro Takihara},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 50},
  pages={21529-34}
}
Retrovirus-mediated transduction of Hoxb4 enhances hematopoietic stem cell (HSC) activity and enforced expression of Hoxb4 induces in vitro development of HSCs from differentiating mouse embryonic stem cells, but the underlying molecular mechanism remains unclear. We previously showed that the HSC activity was abrogated by accumulated Geminin, an inhibitor for the DNA replication licensing factor Cdt1 in mice deficient in Rae28 (also known as Phc1), which encodes a member of Polycomb-group… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 35 references

Replication licensing : De fi ning the proliferative state ?

M Ohtsubo
Trends Cell Biol • 2008

HOXB4's road map to stem cell expansion.

Proceedings of the National Academy of Sciences of the United States of America • 2007

The Ink 4 a tumor suppressor gene product , p 19 Arf , interacts with MDM 2 and neutralizes MDM 2 ’ s inhibition of p 53

L LeCam
Cell • 2006

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