Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae.

  title={Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae.},
  author={Kyriakos D Economides and Lori M Zeltser and Mario R Capecchi},
  journal={Developmental biology},
  volume={256 2},
To address the expression and function of Hoxb13, the 5' most Hox gene in the HoxB cluster, we have generated mice with loss-of-function and beta-galactosidase reporter insertion alleles of this gene. Mice homozygous for Hoxb13 loss-of-function mutations show overgrowth in all major structures derived from the tail bud, including the developing secondary neural tube (SNT), the caudal spinal ganglia, and the caudal vertebrae. Using the beta-galactosidase reporter allele of Hoxb13, also a loss-of… CONTINUE READING
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