Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.

@article{Hrycaj2015Hox5GR,
  title={Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.},
  author={Steven M. Hrycaj and Briana R. Dye and Nicholas C Baker and Brian M. Larsen and Ann Campbell Burke and Jason R Spence and Deneen M Wellik},
  journal={Cell reports},
  year={2015},
  volume={12 6},
  pages={903-12}
}
Hox genes are required for proper anteroposterior axial patterning and the development of several organ systems. Here, we show that all three Hox5 paralogous genes play redundant roles in the developing lung. Hoxa5;Hoxb5;Hoxc5 triple-mutant embryos develop severely hypoplastic lungs with reduced branching and proximal-distal patterning defects. Hox5 genes are exclusively expressed in the lung mesoderm; however, defects are observed in both lung mesenchyme and endodermally derived epithelium… CONTINUE READING
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