Hox genes in vertebrate development

@article{Krumlauf1994Hox,
  title={
 Hox genes in vertebrate development},
  author={Robb Krumlauf},
  journal={Cell},
  year={1994},
  volume={78},
  pages={191-201}
}
CTDGFinder: A Novel Homology-Based Algorithm for Identifying Closely Spaced Clusters of Tandemly Duplicated Genes
TLDR
A novel homology-based algorithm, CTDGFinder, which formalizes and automates the identification of CTDGs by examining the physical distribution of individual members of families of duplicated genes across chromosomes and will facilitate understanding ofCTDG evolutionary dynamics, their functional implications, and how they are associated with phenotypic diversity.
A novel homology-based algorithm for the identification of physically linked clusters of paralogous genes
TLDR
A novel homology-based algorithm, CGPFinder, which formalizes and automates the identification of clusters of gene paralogs (CGPs) by examining the physical distribution of individual gene members of families of paralogous genes across chromosomes.
RARβ mediates the response of Hoxd4 and Hoxb4 to exogenous retinoic acid
TLDR
It is concluded that there are no synergistic interactions between Hoxd4 and Rarb in the specification of the cervical vertebrae and the results strongly suggest that RARβ is a mediator of their RA‐response.
Separate cis-acting elements determine the expression of mouse Dbx gene in multiple spatial domains of the central nervous system
TLDR
Results suggest that major cis-acting elements reside within a 5.7 kb DNA fragment located 5' of the Dbx gene, which is sufficient to direct the expression of the transgene to various domains of the CNS in a temporally regulated fashion.
Molecular characterization of HOXC8 gene and methylation status analysis of its exon 1 associated with the length of cashmere fiber in Liaoning cashmere goat
TLDR
The methylation analysis suggested that the methylation degree of HOXC8 exon 1 in anagen secondary hair follicle might be involved in regulating the growth of cashmere fiber in Liaoning cashmere goat.
Analysis of HOXA 5 expression and function in development of the central nervous system
The Hox genes encode transcription factors that are indispensable for proper spatiotemporal patterning of the vertebrate body axes. As for other Hox genes, region-specific expression of Hoxa5 appears
Traditional Chinese Medicine, the Zishen Yutai Pill, Ameliorates Precocious Endometrial Maturation Induced by Controlled Ovarian Hyperstimulation and Improves Uterine Receptivity via Upregulation of HOXA10
TLDR
The traditional Chinese medicine, the Zishen Yutai pill, has been found to ameliorate precocious endometrial maturation in a mouse model of different COH and improve uterine receptivity by upregulating HOXA10.
Collinear regulations of vertebrate Hox gene clusters: structural constraints and evolutionary innovations
TLDR
The recent genome analyses of various species and their embryonic Hox gene expression patterns suggest that Hox cluster architecture and gene position inside the complexes have important implications for the transcriptional regulation of this gene family in various developmental contexts.
DNA replication, development and cancer: a homeotic connection?
TLDR
The homeotic proteins, by participating directly in the function of DNA replication origins, may provide a direct link between the accurate regulation ofDNA replication required by the morphogenetic program and the deregulation of this process typical of cancer.
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References

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TLDR
A systematic series of clustered point mutations in module E revealed that an additional region containing an imperfect inverted repeat sequence is also required for the function of this homeotic protein response element, demonstrating strong evidence that the in vitro‐defined binding site is a direct target of Dfd protein in embryos.
Homeotic genes and positional signalling in the Drosophila viscera.
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  • Biology, Medicine
    Trends in genetics : TIG
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Homeotic genes play a key regulatory role in the two innermost germ layers of Drosophila, the visceral mesoderm and the endoderm. Here, they control, and are controlled by, genes that encode
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The high rate of induction and recovery of point mutations, in addition to an efficient aquarium system to house large numbers of mutagenized lines, means that it is now possible to perform saturation mutagenesis screens in a vertebrate, similar to those done in invertebrates.
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TLDR
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TLDR
Examination of Kox-20 expression at stages as early as E8.5 indicates that Krox-20 fails ever to be expressed in its r5 domain in the homozygous kreisler mutant, and it appears that the fundamental defect is a loss of r5 and r6.
HOM/Hox genes of Artemia: implications for the origin of insect and crustacean body plans
TLDR
All the homeotic genes that specify middle body regions in insects originated before the divergence of the insect and crustacean lineages, probably not later than the Cambrian (about 500 million years ago).
Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest
TLDR
Analysis of stained skeletons revealed that homozygous mutant animals contained multiple cranial skeletal defects, including a duplication of the ossification centers of the bones of the middle ear.
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