Hox genes and segmentation of the hindbrain and axial skeleton.

@article{Alexander2009HoxGA,
  title={Hox genes and segmentation of the hindbrain and axial skeleton.},
  author={Tara B. Alexander and Christof Nolte and Robb Krumlauf},
  journal={Annual review of cell and developmental biology},
  year={2009},
  volume={25},
  pages={
          431-56
        }
}
Segmentation is an important process that is frequently used during development to segregate groups of cells with distinct features. Segmental compartments provide a mechanism for generating and organizing regional properties along an embryonic axis and within tissues. In vertebrates the development of two major systems, the hindbrain and the paraxial mesoderm, displays overt signs of compartmentalization and depends on the process of segmentation for their functional organization. The… 
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This review investigates how the RA signaling machinery has evolved and diversified and discusses its connection to the hindbrain GRN in relation to diversity, and describes the value of using lamprey as a model for the early-diverged jawless vertebrate group to investigate the elaboration of A-P patterning mechanisms in the vertebrate lineage.
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References

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