How will CCR5 antagonists influence the recommendations for the antiretroviral treatment of HIV-1 infection.

@article{Lunzen2007HowWC,
  title={How will CCR5 antagonists influence the recommendations for the antiretroviral treatment of HIV-1 infection.},
  author={Jan van Lunzen},
  journal={European journal of medical research},
  year={2007},
  volume={12 9},
  pages={435-40}
}
The new antiviral CCR5 antagonists have proven to be highly efficient in treatment experienced patient populations with multiple drug failure. Maraviroc is the most advanced compound in clinical development representing this new class of entry inhibitors. The favourable toxicity-, resistance- and pharmacokinetic profile of the drug has been proven in phase III trials in treatment naive and experienced patients. In the latter population, maraviroc had superior antiviral efficacy and… CONTINUE READING