How were new medicines discovered?

@article{Swinney2011HowWN,
  title={How were new medicines discovered?},
  author={D. Swinney and J. Anthony},
  journal={Nature Reviews Drug Discovery},
  year={2011},
  volume={10},
  pages={507-519}
}
Preclinical strategies that are used to identify potential drug candidates include target-based screening, phenotypic screening, modification of natural substances and biologic-based approaches. [...] Key Method To investigate whether some strategies have been more successful than others in the discovery of new drugs, we analysed the discovery strategies and the molecular mechanism of action (MMOA) for new molecular entities and new biologics that were approved by the US Food and Drug Administration between…Expand
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