How well does structural equation modeling reveal abnormal brain anatomical connections? An fMRI simulation study

@article{Kim2009HowWD,
  title={How well does structural equation modeling reveal abnormal brain anatomical connections? An fMRI simulation study},
  author={Jieun Kim and Barry Horwitz},
  journal={NeuroImage},
  year={2009},
  volume={45 4},
  pages={1190-8}
}
Many brain disorders result from alterations in the strength of anatomical connectivity between different brain regions. This study investigates whether such alterations can be revealed by examining differences in interregional effective connectivity between patient and normal subjects. We applied one prominent effective connectivity method - Structural Equation Modeling (SEM) - to simulated functional MRI (fMRI) timeseries from a neurobiologically realistic network model in which the… CONTINUE READING